Targeting Axl With an High-affinity Inhibitory Aptamer
نویسندگان
چکیده
منابع مشابه
Tumor targeting by an aptamer.
UNLABELLED Aptamers are small oligonucleotides that are selected to bind tightly and specifically to a target molecule. We sought to determine whether aptamers have potential for in vivo delivery of radioisotopes or cytotoxic agents. METHODS TTA1, an aptamer to the extracellular matrix protein tenascin-C, was prepared in fluorescent and radiolabeled forms. After in vivo administration, uptake...
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A design strategy for high-affinity aptamers of complex biomolecules is presented. We developed an RNA with FAD-binding properties by combining known ATP- and FMN-aptamers. Cooperative binding of FAD was shown by SPR spectroscopy and fluorescence assays. The strategy should be transferable to several other biomolecules.
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2012
ISSN: 1525-0016
DOI: 10.1038/mt.2012.163